Livedoid vasculitis - Livedoid Vaskulīts
Livedoid Vaskulīts (Livedoid vasculitis) ir hroniska ādas slimība, kas galvenokārt skar jaunākas līdz pusmūža sievietes. Viens no akronīmiem, ko izmanto, lai aprakstītu tās pazīmes, ir “Sāpīgas purpura čūlas ar apakšējo ekstremitāšu retikulāru rakstu” (PURPLA). Tas ir saistīts ar vairākām slimībām, tostarp hronisku venozo hipertensiju un varikozām vēnām.
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2022. gada Stiftung Warentest rezultātos no Vācijas patērētāju apmierinātība ar ModelDerm bija tikai nedaudz zemāka nekā ar maksas telemedicīnas konsultācijām.
2022. gada Stiftung Warentest rezultātos no Vācijas patērētāju apmierinātība ar ModelDerm bija tikai nedaudz zemāka nekā ar maksas telemedicīnas konsultācijām.
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ReferencesLivedoid vasculopathy ir reta ādas slimība, ko raksturo sāpīgas čūlas, kas bieži parādās uz apakšstilbiem.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy ir reta ādas slimība, kas izraisa atkārtotas čūlas uz apakšstilbiem, atstājot bālas rētas, pazīstamas kā atrofiskā blanša. Lai gan precīzs cēlonis joprojām nav skaidrs, tiek uzskatīts, ka galvenais faktors ir palielināta asins recēšana (hypercoagulability), bet iekaisumam ir sekundāra loma. Recēšanu veic šādi faktori: proteīnu C un S trūkums, ģenētiskās mutācijas, piemēram, faktors V Leiden, antitrombīna III trūkums, protrombīna gēna mutācijas, kā arī paaugstināts homocisteīna līmenis. Biopsijās redzama asins recekļu veidošanās traukos, asinsvadu sieniņu sabiezēšana un rētas. Ārstēšana ietver daudzpusīgu pieeju, koncentrējoties uz asins recekļu novēršanu ar tādām zālēm kā pret trombocītu līdzekļi, asins šķidrinātāji un fibrinolītiskā terapija. Šim ādas stāvoklim var izmantot dažādas zāles – colchicine, hydroxychloroquine, vazodilatatori, imūnsupresori.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy ir reta slimība, kuras bojājumi rodas abās kājās. Tiek uzskatīts, ka asins recekļu veidošanos mazos asinsvados izraisa pastiprināta recēšana, samazināta trombu sadalīšanās un asinsvadu apvalka bojājumi. Tā ir biežāk sastopama sievietēm, īpaši vecumā no 15 līdz 50 gadiem. Smēķēšanas atmešana, brūču kopšana un tādu medikamentu kā asins šķidrinātāji un pret trombocītu līdzekļu lietošana ir bijusi efektīva.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
